Dr. Mohammed Khalil
is specialized in the field of natural product chemistry. His experience encompassed the classical isolation and structure elucidation of natural products along with their analysis using modern analytical techniques, e.g. HPLC and GC. He got his Ph.D. at Braunschweig Institute of Technology, Germany where his experience is expanded to the fields of plant tissue culture and elucidation of biosynthesis of natural products on both the biochemical and molecular levels. Successfully, he contributed to gene isolation, cloning, and functional characterization of O-methyltransferases involved in the biosynthesis of phytoalexins produced by Rosaceae species. His work got published in highly ranked Journals, e.g., Plant Journal, Food Chemistry, and Phytochemistry. After returning to his home university, Cairo University, he is involved in projects dealing with metabolomics analysis of medicinal plants using LC-QTOF-Ms and LC-MS/MS techniques and the production of valuable natural products using tissue culture techniques.
Some selected publications
- Khalil, M. N., Choucry, M. A., El, A. S., Hassan, A., El-Marasy, S. A., El, S. A., & Omar, F. A. : Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide-induced memory impairment, comparison to curcumin. PloS one, 14(7), (2019). e0219378-e0219378.
- Srour AM, Dawood DH, Khalil MNA, Nofal ZM: Synthesis and 2D-QSAR study of dispiropyrrolodinyl-oxindole based alkaloids as cholinesterase inhibitors. Bioorganic Chemistry, 83: 226-234 (2019)
- Choucry MA, Khalil MNA, El Awdan SA: Protective action of Crateva nurvala Buch. Ham extracts against renal ischaemia reperfusion injury in rats via antioxidant and anti-inflammatory activities. Journal of Ethnopharmacology, 214: 47-57 (2018)
- Farag MA, Fekry MI, Al-Hammady MA, Khalil MNA, El-Seedi HR, Meyer A, Prozel A, Westphal H, Wessjohan LA: Cytotoxic effects of Sarcophyton sp. Soft corals-Is there a correlation to their NMR fingerprints?. Marine Drugs, 15:211-224 (2017).
- Khalil MNA, Fekry MI, Farag MA: Metabolome based volatiles profiling in 13 date palm fruit varieties from Egypt via SPME GC–MS and chemometrics. Food Chemistry, 217: 171-181 (2017).