OSP lankacidin STDF EG/JAPAN
Structural Redesign and Computational Simulation of Lankacidin Analogues to Improve Antitumor Activity
Optimization of lankacidin C to improve its antitumor activity.
Cooperation: Assoc. Prof. Dr. Kenji Arakawa
Structural Redesign and Computational Simulation of Lankacidin Analogues to Improve Anti-tumor Activity
- Docking of lankacidin derivatives
- Docking of M51 derivatives
- Molecular dynamics and MMPBSA of lankacidin derivatives
- Molecular dynamics and MMPBSA of M51 derivatives
- Synthesis of lankacidin derivatives
- Synthesis of M51 derivatives
Cooperation: Rasha Radwan-Kenji Arakawa
“Structural redesign and computational simulation of lankacidin analogues to improve anti-tumour activity.”
The objective of this project is to provide a potent anticancer drug which will help save the lives of millions of people around the world. By modification of lankacyclinone C and improvement of the synthesizability of M51, the two themes are expected to lead to microtubule-stabilizing agents which would strongly bind to microtubules during cell division and force them to commit suicide, thus eliminating cancer cells from the body. Another important objective of the study is to facilitate the acquisition of Masters/PhD degrees for the graduate students in the Egyptian team as well as the Japanese team. Egyptian students will be given the chance to travel to Japan and gain experience regarding large scale fermentation processes as well as take advantage of the state-of-the-art equipment which will be necessary all along with the project. Japanese students will have the chance to come to Egypt and train on computational simulations as well as biological evaluation of cytotoxicity and cell culture techniques.
Cooporation: Ahmed Taha Ayoub-Egypt /Kenji Arakawa-japan
OSP Moringa Oleifera-Dithiocarbamates
Moringa Oleifera dithiocarbamates fungicide assay
The primary objective of this project is to detect and quantify, at the lowest detectable amounts, the fungicidal dithiocarbamate compound Mancozeb in the leaves of Moringa Oleifera by means other than the official GC method. The detection of DTCs by gas chromatography relies solely upon the detection of CS2 gas produced by heating the sample during the steps of analysis; this makes the method incapable of differentiating between different DTCs if present in one sample or their source. Mancozeb (Chemical name: Ethylenebisdithiocarbamate Manganese-Zinc), is one of the dithiocarbamates family of fungicides widely used in agriculture. It can be described as the sum of two compounds: Maneb (Manganese EBDTC) and Zineb (Zinc EBDTC). Issues expected to be encountered in this work include the poor solubility of the compound as well as related compounds in water and most organic solvents. Another challenge is to find and validate a method that is accurate, sensitive, and discriminative between the naturally-occurring carbamates in Moringa Oleifera and the industrial fungicide possibly contaminating the plant.
Study on the detection of mancozeb residues on Moringa leaves by HPLC.
The aim of this study is to provide reliable methods to specifically detect mancozeb residues on Moringa leaves, other than detection of CS2 levels.
PROTOCOL FOR DETECTION OF MANCOZEB FUNGICIDE RESIDUE BY THIN LAYER CHROMATOGRAPHY SPOT TEST
The aim of this protocol is to test and validate a thin layer chromatographic method for the detection of Mancozeb fungicide residue against aqueous/ ethanolic Moringa Oleifera leaves extract. TLC spot test is simple, inexpensive and reliable amongst the more sophisticated methods of analysis. Mancozeb (ethylene-bis-dithiocarbamate Manganese-Zinc), one of the dithiocarbamate fungicides, is a mixture of Maneb (Manganese ethylene-bis-dithiocarbamate) and Zineb (Zinc ethylene-bis-dithiocarbamate).
Construction of biocrystallization lab [Enhancing the Quality of Organic Agricultural Activities in Egypt Through a Center of Excellence in Biological and Integral Quality Assurance for Organic Agriculture (CIQuA)}
- Quality determination of food products is predominantly based on quantitative
- compound analyses, which reduces biological systems to chemical & physical phenomena.
- Distinguishing between organic and conventional food products.
- Develop standardized, validated, scientifically acknowledged & communicable method of evaluation of organic crystallization pictures.
- Cooperation: Dr. Paul Doesburg -Crystal Lab Dr. Nicolaas Busscher-University of Kassel
Oral Pharmacokinetics of an Investigational Substance Ciprodiazole Tablet “Ciprofloxacin 500 mg + Metronidazole 500mg”
Investigation of Absorption, Distribution, Metabolism and Excretion profiles of Ciprodiazole Tablet consisting of 500 mg Ciprofloxacin and 500mg Metronidazole in female rats.
Cooperation: Dr. Fathy Ibrahim-ICBR
Efficacy of Hexamine, Khelline and Piperazine combination (Coli-Urinal) in Lower Urinary Tract Infection. Open Labelled Study (ECU)
Primary objective: is an evaluation of Coli-Urinal efficacy as a urinary tract antiseptic in patients with lower urinary tract infection.
The secondary objective: is monitoring changes in urine pH value and evaluation of clinical improvement using “core lower urinary tract symptom score”
Cooperation: Dr. Fathy Ibrahim / Dr. Ahmed Elbaz
To deliver the following outputs Standardized extracts of caraway, anise, and fenugreek. Monographs for caraway and anise extract. Batch manufacturing methods of the herbal extracts.
Safety and Efficacy of an Investigational Medicinal Product “MEE-HU
Medicus”, in Combination with Antimicrobial, in Urinary Tract Infection A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study (SEM)
Primary objective: is an evaluation of the investigational product's safety and evaluation of its effect, in combination with antimicrobial treatment, on urine culture (microbiological cure, no microbial growth on 24-48 hrs culture). The secondary objective: is an evaluation of the investigational product's effect, in combination with antimicrobial treatment, on disease-related symptoms (Clinical cure, the disappearance of symptoms and signs).
Cooperation: Mr. Arnold Schmidt / Dr. Ahmed Elbaz /
Dr. Rahsad Barsoum
Extraction of Pectin from Citrus Fruit Peels
Production of pharmaceutical grade pectin
Cooperation: Dr. Mamdouh Aboleish